Brief Description
Aromatic Roots which promotes urine production.
चरकसंहिता - सूत्रस्थानम् - २७. अन्नपानविध्यध्यायः
रोचनो दीपनो हृद्यः सुगन्धिस्त्वग्विवर्जितः| कर्चूरः कफवातघ्नः श्वासहिक्कार्शसां हितः||१५५||
अभिधानमञ्जरी - मदनादिगणवर्ग - ३१. एलादिवर्ग
चोरक अन्ध्रो विषमो विषगन्धः षट्प्रजश्च गन्धाली | षड्ग्रन्धा दुष्पत्रो धूर्तश्च शटी विटः षडी पर्णी ||
ग्रन्थिपर्णो दौष्कुलेयस्त्वक्शरो गन्धिनी वधूः | सुगन्धमूलौषधी च सुप्रजा च निशाचरा ||
आर्द्रगन्धः पलाशश्च हर्ता पृथुपलाशिका | चोराभिधाना विज्ञेया शब्दैः पर्यायवाचकैः ||३७९||
अन्या कृष्णशटी स्यादार्षः सापुः शिवश्च शीतशिवः | शीतश्च सिद्धकालः सौम्यकरश्चेति सितगन्धः ||
सैवोच्यते बली वृन्दी धूमानलवधूः प्रिया | अजाप्रियो ग्रहावासः शिलाख्यः कृष्णचोरकः ||३८०||
अमरकोश -द्वितीयकाण्ड - १. वनौषधिवर्ग
संस्पर्शाथ शटी गन्धमूली षड्ग्रन्थिकेत्यपि | कर्चूरोऽपि पलाशोऽथ कारवेल्लः कटिल्लकः ||१५४||
कैयदेवनिघण्टु - १. ओषधिवर्ग
जीमूतमूलं कर्चूरो द्राविडो वेधमुख्यकः ||१३८८||
कार्ष्यकाप्यो गन्धमूलः काल्पको दुर्बलः सठी | कर्चूरः कटुकस्तिक्तस्तीक्ष्णो दीपनो लघुः ||१३८९||
रोचनः कटुपाकोऽस्रपित्तकृत् कफवातजित् | श्वासकासकृमिप्लीहकुष्ठार्शोव्रणगुल्मनुत् ||१३९०||
कैयदेवनिघण्टु - १. ओषधिवर्ग
गन्धालिरिका गन्धवधूर्वधूः पृथुपलाशिका | शठी सुगन्धचूडा स्यात् सोमदा सोमसम्भवा ||१३९१||
सुगन्धमूला षड्ग्रन्था सुव्रता सुगृहीतिका | सटी कच्चूरा इति भाषा प्रसिद्धा |
शठी तिक्तकटुस्तीक्ष्णा कषाया ग्राहिणी लघुः ||१३९२||
अनुष्णा मुखवैरस्यमलदौर्गन्धनाशिनी | दोषकासव्रणश्वासशूलहिध्माज्वरापहा ||१३९३||
धन्वन्तरिनिघण्टु - १. गुडूच्यादिवर्ग
शटी शठी पलाशश्च ज्ञेया पृथुपलाशिका | सुगन्धमूला गन्धाली षड्ग्रन्था सुव्रता वधूः ||६५||
चन्द्राणी चन्द्रगन्धा च दुर्विधेयेति सञ्ज्ञिता ||६६|| शटी स्यात्तिक्ततीक्ष्णोष्णा सन्निपातज्वरापहा ||६७||
कफोग्रव्रणकासघ्नी वक्त्रशुद्धिविधायिनी ||६८||
निघण्टुशेष - २. गुल्मकाण्ड
शट्यां पलाशः षड्ग्रन्था गन्धोली हिमजा वधूः | कर्चूरः सुव्रता गन्धमूली पृथुपलाशिका ||२३२||
निघण्टुशेषटीका व्याख्या (श्रीवल्लभगणि कृत)
शट रुजा-विशरण-गत्यवसादनेषु शटति शटी, अचि ङीः| केचित् षटीति मूर्धन्यादिमाहुः, शढीत्यपि, तस्याम्| पलाशाः सन्त्यस्य पलाशः, अभ्रादित्वादः| षड् ग्रन्थयोऽस्याः षड्ग्रन्था| गन्धयति-अर्दयति गन्धोली, “पिञ्छोल-कल्लोल-” [हैमोणादिसू. ४९५] इत्योले निपात्यते| हिमे जाता हिमजा| उह्यते वधूः, “वहेर्ध् च” [हैमोणादिसू. ८२२] इत्यूः| करोति कर्चूरः, “सिन्दूर-कर्चूर-पत्तूर-धत्तूरादयः” [हैमोणादिसू. ४३०] इत्यूरे निपात्यते| शोभनो(?नं) व्रतो(?तम)ऽस्याः सुव्रता| गन्धयुक्तं मूलमस्याः गन्धमूली| पृथ्वी चासौ पलाशिका च पृथुपलाशिका| आह च–
शटी षटी पलाशः स्यात् ज्ञेया पृथुपलाशिका|
सुगन्धमूला गन्धोली षड्ग्रन्था सुव्रता वधूः|| [धन्व. वर्ग १ श्लो. ६१] इति|
शटीनामानि| लोके तु ‘शढि’ इति प्रसिद्धिः||२३२||
निघण्टुशेष - २. गुल्मकाण्ड
कर्चूरे द्राविडः काल्यो वेधाग्र्यो गन्धमूलकः ||२५५||
निघण्टुशेषटीका व्याख्या (श्रीवल्लभगणि कृत)
कृन्तति त्वग्दोषं कर्चूरः, सिन्दूर-कर्चूर-पत्तूर-धत्तूरादयः [हैमोणादिसू. ४३०] इत्यूरे निपात्यते, तत्र| द्रावयति द्राविडः, विहड-कहोड- [हैमोणादिसू. १७२] इत्यडे निपात्यते| “कल्यकारी काल्यः” इति क्षीरस्वामी| वेधे अग्र्यः-श्रेष्ठो वेधाग्र्यः| गन्धयुक्तं मूलमस्य गन्धमूलः, गन्धो मूले अस्येति वा, के गन्धमूलकः| आह च–
कर्चूरको गन्धमूलो द्राविडः काल्य एव च|
वेधमुख्यो दुर्लभश्च कस्यचित् सम्मता शटी|| [धन्व. वर्ग ३ श्लो. ९४] इति|
अमरोऽपि-
कर्चूरको द्राविडकः काल्यको वेधमुख्यकः| [अमर. का. २ वर्ग ४ श्लो. १३५] इति|
एतस्य लोके कचूर इति प्रसिद्धिः||२५५||
भावप्रकाश-पूर्वखण्ड-मिश्रप्रकरण - ३. कर्पूरादिवर्ग
कर्चूर
कर्चूरो वेधमुख्यश्च द्राविडः कल्पकः शटी | कर्चूरो दीपनो रुच्यः कटुकस्तिक्त एव च |
सुगन्धिः कटुपाकः स्यात्कुष्ठार्शोव्रणकासनुत् | उष्णो लघुर्हरेच्छ्वासं गुल्मवातकफक्रिमीन् ||८०||
भावप्रकाश-पूर्वखण्ड-मिश्रप्रकरण - ३. कर्पूरादिवर्ग
शटी
शठी पलाशी षड्ग्रन्था सुव्रता गन्धमूलिका | गन्धारिका गन्धवधूर्वधूः पृथुपलाशिका ||८२||
भवेद्गन्धपलाशी तु कषाया ग्राहिणी लघुः | तिक्ता तीक्ष्णा च कटुकानुष्णास्यमलनाशिनी |
शोथकासव्रणश्वासशूलसिध्मग्रहापहा ||८३||
मदनपालनिघण्टु - ३. कर्पूरादिवर्ग
कर्चूर
कर्चूरो द्राविडो गन्धमूलको दुर्लभः शटी | कर्चूरो दीपनो रुच्यः कुष्ठार्शोव्रणमूत्रजित् |
उष्णो लघुर्जयेच्छ्वासगुल्मवातकफक्रिमीन् ||५५||
माधवद्रव्यगुण - १. विविधौषधिवर्ग
शटी वातकफश्वासकासज्वरहरी मता ||१३५||
राजनिघण्टु - ६. पिप्पल्यादिवर्ग
कर्चूर
कर्चूरो द्राविडः कार्शो दुर्लभो गन्धमूलकः | वेधमुख्यो गन्धसारो जटिलश्चाष्टनामकः ||११७||
कर्चूरः कटुतिक्तोष्णः कफकासविनाशनः | मुखवैशद्यजननो गलगण्डादिदोषनुत् ||११८||
राजवल्लभनिघण्टु - २. पौर्वाह्णिकपरिच्छेद
शटी अनुलेपनगुण
शटी वातकफश्वासकासज्वरविनाशिनी ||१४५||
सोढलनिघण्टु - नामसङ्ग्रह (प्रथम भाग) - १. गुडूच्यादिवर्ग
शट्यां शटीपलाशश्च ज्ञेया पृथुपलाशिका | सुगन्धमूला गान्धारी षड्ग्रन्था सुव्रता वधूः ||१३७||
गुडूच्यादिरयं वर्गः प्रथमः परिकीर्तितः | ऊर्ध्वाधोदोषहरणः सर्वामयविनाशनः ||२३||
सोढलनिघण्टु - नामसङ्ग्रह (प्रथम भाग) - ३. चन्दनादिवर्ग
कर्चूरे गन्धमूलश्च द्राविडः कर्ष एव च | वेधमुख्यो दुर्लभश्च कस्यचित् सम्मतः शटी ||४३२||
Dihydrocurcumin
Isoprocurcumenol
Procurcumenol
Gweicurculactone
Zederone
Zedoaronediol
Zerumbone epoxide
Zerumin A
Epicurzerenone
Curzerenone
Zederone
Germacrone
Beta turmerone
Ethyl p methoxycinnamate
Beta eudesmol
Zingiberene
Dihydrocurcumin
Furanodiene
Furanodienone
1,8 - Cineole
Beta elemense
| Sl.No | Raw Material | Variant | Ratio | Quantity Required for 1000g | Unit |
|---|
| Rasa | कटु - Katu - Pungent तिक्त - Tikta - Bitter कषाय - Kashaya - Astringent |
|---|---|
| Guna | लघु गुणम् - Laghu Gunam - Drug property which induces lightness to body तीक्ष्णम् - Tikshnam - Drug action which irritates body by its Pungent quality उष्णं गुणम् - Ushna Gunam - Drug action which imparts heat स्निग्ध गुणम् - Snigdha Gunam - Drug action which imparts unctuousness श्लक्ष्ण गुणम् - Shlakshna Gunam - Drug property which imparts smoothness द्रव गुणम् - Dravagunam - Drug action which imparts liquid state मृदु गुणम् - Mrudu Gunam - Drug action which imparts softness सर गुण - Saraguna - Drug action which imparts movement सूक्ष्म गुणम् - Sukshma Gunam - Drug property by virtue of which molecules of drug can eneter into minutetst spaces of body विशद गुणम् - Vishada Gunam - Drug action which cleanses the body |
| Veerya | Ushna veerya |
| Vipaka | Katu |
| Prabhava | मूत्रकृच्छ्रहरम् - Mutrakrichraharam - Pharmacological action which cures obstructive uropathy or painful micturition |
| Anupanam | रोगोपशमन अनुपानम् - Anupana according to the diseases. | modal-content
| Sl.No. | Disease Factor | Name of the combination | Form of the combination | Reference | Combination products | Procedure |
|---|
| Disease Factors |
|---|
| Serial Number | Title | Result |
| 1 | Curcuma zedoaria Rosc (Zingiberaceae): a review on its chemical, pharmacological and biological activities | The present review investigation is very much helpful for researchers and readers to collectively have valuable information on chemistry, pharmacology and biological effects of Curcuma zedoaria Rosc. The present investigation concludes that the white turmeric is found to possess complex range of phytoconstituents such as curcumin, ethyl p-methoxycinnamate, β-turmerone, β-eudesmol, zingiberene, dihydrocurcumin, furanodiene, α-phellandrene, 1–8 cineole, β-elemense and germacrone. Due to the presence of wide range of phytoconstituents, plants have been reported for its diverse biological activities. |
| 2 | Anti-inflammatory sesquiterpenes from Curcuma zedoaria | From the methanolic extract of the rhizome of Curcuma zedoaria, we isolated anti-inflammatory sesquiterpene furanodiene (1) and furanodienone (2) along with new sesquiterpene compound 3 and known eight sesquiterpenes, zederone (4), curzerenone (5), curzeone (6), germacrone (7), 13-hydroxygermacrone (8), dehydrocurdione (9), curcumenone (10), and zedoaronediol (11). Their structures were elucidated on the basis of spectroscopic data. The anti-inflammatory effect of isolated components on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation of mouse ears were examined. Compounds 1 and 2 suppressed the TPA-induced inflammation of mouse ears by 75% and 53%, respectively, at a dose of 1.0 µmol. Their activities are comparable to that of indomethacin, the normally used anti-inflammatory agent. |
| 3 | Antioxidant and antibacterial activities of the rhizome extract of Curcuma zedoaria extracted using some organic solvents | Curcuma zedoaria extract produces alkaloids, phenolics, flavonoids, saponins, coumarins, and triterpenoids when fractionated with MeOH or EtOAc. Only alkaloids and triterpenoids are produced using n-hexane. EtOAc and MeOH fractions have good activity in reducing free radicals generated by DPPH, with an average IC50 value of 153.49 ± 2.66 and 185.77 ± 3.91 ppm, respectively. However, n-hexane has weak antioxidant activity, with an average IC50 value of 837.92 ± 5.32 ppm. All fractions have moderate antibacterial activity, but the extract of n-hexane from C. zedoary has better antibacterial activity compared to MeOH and EtOAc. The lowest concentration required is 2,500 ppm for all types of bacteria |
| 4 | Antitumour Effects of Isocurcumenol Isolated from Curcuma zedoaria Rhizomes on Human and Murine Cancer Cells | The compound isolated from the rhizomes of Curcuma zedoaria, characterized as isocurcumenol by the MS and IR spectra significantly inhibited the cell proliferation in human lung, leukemia, nasopharyngeal carcinoma and murine lymphoma cells. Acridine orange-Ethidium Bromide and Hoechst staining revealed the apoptosis inducing capacity of isocurcumenol. GC-MS profile of the Petroleum ether extract showed isocurcumenol, methyl sterolate, elemene, and Isolongifolene as the prominent chemical constituents. The in vivo studies suggested the non toxic nature of the compound at low doses and its antitumour effects in the ascitic tumour development comparable to the standard drug used to treat lymphoma, cyclophosphamide. The present study highlights the antitumour potential of isocurcumenol isolated from Curcuma zedoaria to be exploited further to be developed as a good antitumour agent. |
| 5 | Effect of Curcuma zedoaria Rosc root extracts on behavioral and radiology changes in arthritic rats | It has also been suggested that FCA-induced RA has a widespread effect on physiological homeostasis due to the severe discomfort in animals. In present studies, the control group showed gradual decrease in ambulatory and rearing behavior and gradual increase in latency time to explore, grooming, urinations, and defecations were observed. However, in drug-treated groups recovery were observed in ambulatory and rearing behavior whereas decrease in latency time to explore grooming, urinations, and defecations. Whereas, methanol groups have failed in all accepts. Radiograph showed increase swelling in control and methanol joints but reduction in drug-treated groups. These observations support the efficacy of extracts treatment in behavior modulation induced by arthritis by decreasing irritation, anxiety, increased intention to walk, and reduction swelling of rats joint. This shows the possible applicability of petroleum ether and chloroform root extracts of Curcuma zedoaria used in symptomatic treatment of arthritis. |
| 6 | Antimicrobial Activity and Cytotoxicity of the Essential Oil of Curcuma zedoaria | The chemical compositions of the essential oil of Curcuma zedoaria (Berg.) Rosc. were analyzed by gas chromatography-mass spectrometry (GC-MS) and showed a high content of epicurzerenone and curdione representing 46.6% and 13.7% of the total oil, respectively. The essential oil was evaluated for potential antimicrobial activity against Staphylococcus aureus, Escherichia coli, Pseudomonasa aeruginosa, Vibrio parahaemolyticus, Salmonella typhimurium and Bacillus cereus. V. parahaemolyticus was sensitive to the presence of the essential oil, while the most resistant strain appeared to be E. coli. Based on 3- (4,5-dimethylthiazol-2-yl)-2, 5-diphenyl-tetrazolium bromide (MTT) assay, nitroblue tetrazolium (NBT) reduction and cell morphology, the essential oil of C. zedoaria could inhibit the proliferation of human promyelocytic leukemia HL-60 cells. These results suggest that the essential oil has the antimicrobial activity against some of Gram- positive and negative pathogenic microorganisms and the components of the extract lead to the apoptosis of human cancer cell line. |
| 7 | Anti-angiogenesis effect of essential oil from Curcuma zedoaria in vitro and in vivo | EO-CZ exhibited anti-proliferative effect on B16BL6 and SMMC-7721 cells, the IC50, respectively was 41.8 μg/ml and 30.7 μg/ml, and on HUVEC (Human Umbilical Vein Endothelial Cells) cells with IC50 of far more than 120 μg/ml. Both 20 μg/ml and 40 μg/ml EO-CZ indicated significant suppression on sprouting vessels of aortic ring and formation of microvessels in chick embryo chorioallantoic membrane in vitro. Moreover, solid melanoma grown in left oxter of mice was obviously inhibited after oral intake of 100 and 200 mg/kg of EO-CZ a day for 28 days, and CD34 expression indicating angiogenesis in melanoma reduced significantly compared with control; melanoma metastatic nodules in lung were detected to be inhibited, as well as MMP-2 and MMP-9 expression in serum.Essential oil, a fat-soluble fraction of Curcuma zedoaria, presented anti-angiogenic activity in vitro and in vivo, resulting in suppressing melanoma growth and lung metastasis. And this was associated with down-regulating MMPs. |
| 8 | Phytopreventive antihypercholesterolmic and antilipidemic perspectives of zedoary (Curcuma Zedoaria Roscoe.) herbal tea | The results of the present study conclude that the strong phenolic contents and radical scavenging activity of zedoary rhizome have protective role against hypercholesterolemic and lipidemic conditions. |
| 9 | Extracts from Curcuma zedoaria Inhibit Proliferation of Human Breast Cancer Cell MDA-MB-231 In Vitro | MDA-MB-231 cells were inhibited by petroleum ether extracts of Curcuma zedoaria (P < 0.05), and the inhibition rate was dependent on concentrations and time. Petroleum ether extracts of Curcuma zedoaria as well as Epirubicin produce a significant G0/G1 cell cycle arrest. The level of expression of proteins E-cadherin and E-cadherin mRNA was significantly increased, while proteins SDF-1, CCR7, and CXCR4 mRNA were decreased after being incubated with petroleum ether extracts of Curcuma zedoaria at the concentrations of 300 μg/mL than control (P < 0.05). The differences were that the protein CXCR4 mRNA expression level was higher than vehicle. Conclusions. MDA-MB-231 cells were inhibited by petroleum ether extracts of Curcuma zedoaria. |
| 10 | Neuroprotective and Antioxidant Constituents from Curcuma zedoaria Rhizomes |
The result obtained from this assay is from the direct quenching of free radicals, which is related to the antioxidant capacity of the molecule itself [43]. All the compounds (1-10) tested, showed strong to moderate antioxidant activity in the order of zerumbone epoxide > zederone > isoprocurcumenol > dehydrocurdione > germacrone (1)> curcumenone > procurcumenol (7)> zerumin A > gweicurculactone (>curcumenol. While zerumbone epoxide , a humulane type sesquiterpene, showed the highest antioxidant capacity (35.41 TE/100 µg sample), and the activity was stronger than that of quercetin (21.16 TE/100 µg sample); in the neuroprotective assay, this compound showed a maximum of 84.32% protection of the cells at the highest concentration tested (30 µM). Interestingly, curcumenol , which showed the strongest neuroprotective activity (100%) among all the compounds tested, exhibited a moderate antioxidant activity (12.62 TE/100 µg sample). This suggests that the neuroprotective activity of this compound is not the sole contributor from its antioxidant activity, rather a combined effect of its anti-inflammatory, antioxidant and NO-production inhibitory activity. In case of zerumbone epoxide , the effect might be chiefly due to its antioxidant property. Dehydrocurdione (2), the other compound with strong neuroprotective activity, showed an antioxidant capacity of 26.18 TE/100 µg sample, higher than the standard, quercetin |
| 11 | The effects of Curcuma zedoaria oil on high blood sugar level and gingivitis |
abstract Background: Hyperglycemia is a condition when blood sugar level is higher than normal. Hyperglycemia is also one of diabetes mellitus (DM) symptoms. Hyperglycemia has a correlation with the occurrence of periodontal disease. Curcuma zedoaria oil is known to decrease concentration of serum glucose. Purpose: This study was aimed to determine the effects of Curcuma zedoaria oil on high blood sugar level and gingivitis in rats. Method: This study used twenty-five male Wistar rats, divided into two groups, namely the treatment group and the control group. In the treatment group, fifteen rats were divided into three subgroups (each of which was induced with 10 µ l/ml, 30 µ l/ml and 50 µ l/ml of Curcuma zedoaria oil). The control group was consisted of ten rats, divided into two subgroups, as the positive control group (induced with 10 mg/kg of Glibenclamide) and the negative control group (induced with propylene glycol). Streptozotocin (STZ) (Naclai tesque, Kyoto Japan) with a dose of 40 mg/kg was used to create hyperglycemia condition in those rats. Gingivitis was then made by using silk ligature in those hyperglycemia rats. Silk ligature was twisted at the margin of gingiva anterior mandibular incisors for seven days. After the rats had gingivitis, Curcuma zedoaria oil, glibenclamide and propylene glycol were orally administered for seven days. Their gingivitis condition was observed, and their blood sugar level was measured before and after the induction of STZ and during the treatment. The data obtained were analyzed by using Manova. Result: There were significant differences of blood sugar levels between the treatment group before and after the administration of Curcuma zedoaria oil and the positive control group (p<0.05). Healthy gingiva was then found in the treatment group and the positive control group. Conclusion: Curcuma zedoaria oil can decrease blood sugar level and gingivitis. |
| Type | Operator | Value | Unit | Frequency | Duration | Comment | |
|---|---|---|---|---|---|---|---|
| Adult Dosage | सूक्ष्म चूर्णम् - Sukshma Churnam - Fine Powder | <= | 3 | g | 1 times / day | 15 days | |
| स्वरसम् - Svarasam - Juice | <= | 20 | ml | 3 times / day | 15 days | ||
| Child Dosage | सूक्ष्म चूर्णम् - Sukshma Churnam - Fine Powder | <= | 1.5 | g | 1 times / day | 15 days | |
| स्वरसम् - Svarasam - Juice | <= | 10 | ml | 3 times / day | 15 days |
